by: Dr. Jenny Pronczuk de Garbino
The main objective of the International Programme on Chemical Safety (IPCS) are: chemical risk assessment and communication, reduction, of chemical risks and strengthening national capacities and capabilities for the appropriate environmentally-sound management of chemicals. Its unit on Poisoning, Prevention and Treatment (PPT) deals essentially with activities for the prevention of, preparedness for, and response to emergencies involving human exposure to chemicals, as well as with the diagnosis, management and prevention of poisoning. The unit on Assessment of Risk and Methodologies (ARM) deals mainly with risk assessment and management.
The IPCS is developing a number of activities specifically addressing health issues related to gender and chemicals, and its first phase addresses women's health and chemicals. The activities undertaken relate the two specific issues: (i) the impact of toxic chemicals on women's health, and (ii) the relevant role of women in the prevention of poisoning.
Incidence and circumstances of poisoning.
Although accidental, occupational and intentional poisonings affect both men and women of all ages, the incidence and characteristics of poisoning vary according to gender.
Statistical data is available but is usually limited to specific area, population groups or chemicals of concern, such as pesticides. Therefore, no general conclusions or extrapolations can be made concerning the global incidence of poisoning according to gender. Comparability of data is not possible due to different data collection and analysis methodologies applied. A growing number of publications concerning gender issues are available in the medical literature, but these are predominantly Anglo-Saxon and,in general, not fully descriptive of the specific circumstances of exposure and related issues (e.g., social, economic, demographics, cultural aspects).
A survey undertaken by the IPCS in 1992-1993 on statistical data registered by Poisons Control Centers (PCCs) demonstrated that, in general, poisoning cases tend to be more frequent in males (only 9 out of 33 PCCs reported higher incidence of poisoning in females) The higher incidence of poisoning in males may be explained by the fact that (a) accidental poisoning is more frequent in small boys, and (b) occupational poisoning predominantly affects the male population. If these two specific circumstances of poisoning are excluded, poisoning in adolescent, adult and elderly women is more common than in the male population. Another study was undertaken reviewing the annual reports produced by 27 PCCs in 1991, 1992 and 1993. The global incidence of toxic exposure was approximately the same i men and women. However, it was observed that data reported by centers which provide occupational health services, showed a higher incidence of toxic exposures in women.
Global figures show that the incidence f poisoning is approximately equal in both sexes. However, differences do arise when global figures are analyzed in relation to circumstances of exposure and age groups affected. For example, Small boys are more prone to accidental ingestion of chemicals or plants than girls, and men are exposed to chemicals in the industrial setting more frequently than women. The suicide and parasuicide rate among women is higher in some Asian countries as compared to that of Western countries. This may be explained by tradition which favors boys, and places less value on the lives of girls. Furthermore, traditional literature and theater often portrays suicide as an honorable choice for women in distress rather than an act for which they may be stigmatized (The Economist, 1997). Suicides and parasuicides tend to be successful in countries where the health sector is not appropriately trained or equipped to handle severe cases, such as poisoning by pesticides or other very ubiquitous and popular poisons. Therefore, the death rate due to poisoning tends to be high in developing countries.
In other countries, anxiolytics, antidepressants, analgesics, and barbiturates are commonly ingested by women, usually with alcohol, in order to commit suicide (Barraca et at, 1993; Mendelson and Rich, 1993; Krut and Zarafiants, 1991; Milev and Mikhov, 1992; Hawton and Fagg, 1992; Henderson et at, 1993; Naidoo and Pillay, 1993).
Another type of poisoning affecting women in particular and reported with increasing frequency in the medical literature is that which is related to the use and abuse of products for losing weight. Hepatocellular liver injury has been reported following the chronic use of herbal "diet" medicines (Pauwels et al, 1992). Around 60 cases of renal insufficiency occurred in Belgium due to toxic plants present as contaminants in Chinese herbal medicines used in diet (Tastemain, 1993). Cases of tetany, rhabdomyolysis, hypokalemia and hypomagnesemia have been reported in relation to surreptitious diuretic ingestion in women concerned about obesity (Brucato et al, 1993). Myopathy and other health effects have been described in women with eating disorders using ipecacuanha syrup as an emetic (Thyagrajan et al, 1993).
Women are also exposed, as well as men, to workplace and environmental pollutants, the effects of which are a matter of concern, particularly in young girls and women of childbearing age. The work done by the IPCS on "Indoor air pollution and its health effects in China - a review" (Chen et al, 1992) demonstrated that indoor pollution is particularly harmful to the health of women and children, especially elderly and reduce its impact on the health of the exposed women.
Some special circumstances and condition in a woman's life are related to the type of toxic exposures they suffer. They are: living and working conditions (e.g., exposure to indoor air pollution, work in the flower or microelectronics industry), pregnancy, social and nutritional discrimination and poor access to health services.
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